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 Brain trauma similar to CTE from blast force is the signature injury of the Iraq and Afghanistan campaigns, afflicting hundreds of thousands of U.S. combat personnel. Although unseen, the damage strikes deeply into a soldier’s mind and psyche 

Recent research has documented high rates of comorbidity between cannabis use disorders and posttraumatic stress disorder (PTSD) in veterans. However, despite possible links between PTSD and cannabis use, relatively little is known about cannabis use in veterans who present for PTSD treatment, particularly among samples not diagnosed with a substance use disorder.

 Internally produced cannabinoids (called endocannabinoids) and phytocannabinoids interact with the Endocannabinoid System through specialized cellular receptors (largely in the nervous system) known as CB1 and CB2 receptors, discovered in the 1990s. CB1 receptors are situated in the brain and central nervous system. In contrast, CB2 receptors are found in the immune system’s organs and tissues, such as the thymus, skin, lymph nodes, bone marrow, spleen, colon, and mucous membranes of the sinus, anus, genitals, nose, bladder, and throat. Both can utilize cannabinoids in one way or another 

Integrative view of eCBs and exogenous cannabinoids in the pathophysiology and potential treatment of PTSD and related processes. Low levels of AEA and/or 2-AG, triggered by stress or pre-existing due to genetic factors, are associated with a myriad of adverse behavioral and physiological consequences including an increase susceptibility to developing trauma-related psychopathology such as PTSD,TBI & CTE Therapeutic eCBaugmentation may be able to reverse these pre-existing or stress-induced deficiencies via inhibition of FAAH or MAGL activity (FAAHi and MAGLi, respectively).